Welcome to Gunma Univ. Graduate school of Medicine Integrative Physiology Nori. Koibuchi Lab.



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New insights into the epigenetic and metabolic actions of thyroid hormone

Paul M. Yen

Laboratory of Hormonal Regulation, Cardiovascular and
Metabolic Disease Program, Duke-NUS Graduate Medical School, Singapore





Voss TC, Schiltz RL, Sung MH, Yen PM, et al. Dynamic exchange at regulatory elements during chromatin remodeling underlies assisted loading mechanism. Cell. 2011; 146: 544-554.

Wang D, Xia X, Weiss RE, Refetoff S, Yen PM. Distinct and histone-specific modifications mediate positive versus negative transcriptional regulation of TSHα promoter. PLoS One 2010; 5:e9853

Wang D, Xia X, Liu Y, Oetting A, Cole PA, Meltzer P, Shi YB, Yen PM. Negative regulation of a target gene by thyroid hormone involves histone acetylation and corepressor complex dissociation. Mol Endocrinol 2009; 23:600-609.

Hu J, Xia X, Cheng A, Wang G, Luo X, Reed MF, Fojo, T. Oetting A, Gong J, Yen PM. A peptide inhibitor targeting p55PIK PI3K regulatory subunit: a novel cancer therapy. Molecular Cancer Therapeutics 2008; 7:3719-3728.

Liu Y, Xia X, Fondell JD, Yen PM. Thyroid hormone regulated genes have distinct patterns of co-activator recruitment and histone acetylation. Mol Endocrinol 2006; 20:483-490.

Maruvada P, NI Dmitrieva, J East-Palmer, Yen PM. Differential expression of thyroid hormone receptor during the cell cycle determines sensitivity to thyroid hormone. Mol Biol Cell 2004; 15:1895-1903.


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